Biotechnology

We have developed the SMARTagTM technology platform, which enables precise, programmable, site-selective chemical

protein modifi cation. Leveraging the target sequence of formylglycine generating enzyme (FGE), we chemoenzymatically

modify proteins to generate a precisely placed aldehyde functionality that can be chemically elaborated. Subsequently, novel

ligation chemistry is employed that exploits this “aldehyde tag” site. We will present recent data on our novel protein modifi cation

platform and its application to generating novel bioconjugates, including ADCs, utilizing our new conjugation chemistries and

linkers. Th e application of these chemistries to generate site-specifi cally modifi ed bioconjugates with improved effi cacy and

safety profi les will be presented. Additionally, we will highlight the progress in developing conjugates with a focus on preclinical

studies as well as highlight our progress in cell line development and manufacturing by using this chemoenzymatic approach.